Ingredient Super Stars
- Hemp Seed Oil, Cocoa & Shea Butter — Certified Organic
- Rosemary Co2 Extract — B-caryophyllene terpene extract
- Vitamin E Oil Natural Non-GMO
- Boswellia carteri (Frankincense) extract
- PBX-Standard Full Spectrum Hemp CBD+CBG extracts
Arti-Rub XL™
Price range: $34.99 through $99.99
Extra strength arthritis and chronic pain relief. 560mg full spectrum CBD+CBG. Fragrance-free formula with Boswellia (Frankincense) extract and B-caryophyllene terpene. Goes on smooth as silk.
Cannabinoid Content
Ingredient Super Stars
- Hemp Seed Oil, Cocoa & Shea Butter — Certified Organic
- Rosemary Co2 Extract — B-caryophyllene terpene extract
- Vitamin E Oil Natural Non-GMO
- Boswellia carteri (Frankincense) extract
- PBX-Standard Full Spectrum Hemp CBD+CBG extracts
Description
Do you suffer from chronic arthritis pain? PurBlend’s Arti Rub Xl to the rescue! Our enhanced formulation now incorporates double the CBD content plus over 50mg of CBG and other cannabinoids making this one of the most powerful PurBlend products to date. This non-oily based formula goes on smooth as silk without all the essential oil fragrance associated with other rubs. The moment this miracle rub contacts warm skin you will feel the relief. With hydrating candelilla wax, organic shea butter, organic hemp seed oil, soothing cocoa and natural vitamin E oil – the Arti Rub Xl is truly magical from top to bottom and provides a big bang in one little tube! Arti Rub Xl may reduce both pain and inflammation without forming a tolerance to its analgesic effects potentially shrinking inflammation and reduced swelling.
Arti Rub Xl contains full spectrum hemp resin extracted from natural hemp strains rich in terpenes and cannabinoids. Arti Rub Xl incorporates B-caryophyllene – a natural terpene working synergistic with other cannabinoids creating superior pain relief. B-caryophyllene is a particularly notable terpene as the only phytocannabinoid outside of the cannabis genus, suppressing pain through the binding and activation of cannabinoid receptors without forming a tolerance to its analgesic effect.
🔬 Want the science behind this? See the full research →
Friendly Ingredients: Candelilla Wax, Organic Shea Butter, Organic Hemp Seed Oil, Cocoa Butter, Non-GMO Vitamin E Oil, Organic Rosemary CO2 Extract, Boswellia carteri (Frankincense) Extract, Beta-Caryophyllene (steam-distilled from Black Pepper), PBX Standard Full Spectrum Hemp Resin (Cannabidiol + Cannabigerol).
All our products are third party tested for Cannabinoids, Terpenes, Volatile Organic Compounds (VOC’s), Heavy Metals, Bacteria, Mycotoxins and Presence of Pesticides.
Built for joint and arthritis discomfort, with four named mechanisms working together — not just a “full spectrum” label.
Arti-Rub XL pairs 560mg of CBD and CBG with three specific, researched actives: Boswellia (frankincense) extract, beta-caryophyllene (steam-distilled from black pepper), and rosemary CO2 extract.
Beta-caryophyllene works alongside CBD, not just next to it. Laboratory research on human skin cells found that CBD and beta-caryophyllene reduce inflammation through two separate, distinct pathways — CBD via the PPARγ receptor, beta-caryophyllene via the CB2 receptor — producing a stronger combined effect than either compound alone.
Boswellia is the best-evidenced ingredient in this formula. Its active compound, AKBA, has been shown to inhibit the 5-LOX enzyme and NF-κB pathway — two specific, real inflammatory targets. In a randomized, placebo-controlled human clinical trial, a topical Boswellia extract applied three times daily for four weeks measurably reduced knee osteoarthritis pain and stiffness compared to placebo. A separate meta-analysis pooling 7 clinical trials and 545 patients found the same result holds up across a broader population.
Rosemary CO2 extract contributes its own real mechanism. Its primary compound, 1,8-cineole, was shown in a human clinical trial to significantly reduce musculoskeletal pain when applied topically — working by inhibiting the same class of inflammatory mediators (prostaglandins, leukotrienes, and cytokines) that the other actives in this formula also target.
CBD and CBG were chosen together deliberately. Research shows CBD and CBG can engage the same receptor family from different angles — CBD through an allosteric binding site that reshapes receptor structure, CBG through mechanisms including the TRPA1 receptor — supporting a more complete anti-inflammatory response than either cannabinoid delivers alone.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
References
- Landucci, E. et al. (2024). Anti-Inflammatory Properties of Cannabidiol and Beta-Caryophyllene Alone or Combined in an In Vitro Inflammation Model. Pharmaceuticals, 17(4):467.
- Evaluation of the effectiveness of topical oily solution containing frankincense extract in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial.
- Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complementary Medicine and Therapies (2020).
- Comparison of the Effect of Topical Application of Rosemary and Menthol for Musculoskeletal Pain in Hemodialysis Patients.
- Nachnani, R., Raup-Konsavage, W.M., Vrana, K.E. (2021). The pharmacological case for cannabigerol. Journal of Pharmacology and Experimental Therapeutics, 376:204-212.
2 reviews for Arti-Rub XL™
Documents & Lab Results
✓ Third-party tested for Cannabinoids, Terpenes, VOCs, Heavy Metals, Bacteria, Mycotoxins & Pesticides.
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This product is produced under the PBX Standard — Pure Botanical Extraction™ — Mark Vuozzo's proprietary quality control program built on the Comerg patented Aerosol extraction platform. Learn more about the PBX Standard →
FDA Disclaimer: PurBlend Science, Inc products contain CBD (cannabidiol) from hemp plants. These products have not been evaluated by the FDA. We are committed to complete compliance with FDA regulations and as such, because these products have not been evaluated by the FDA, we make no claims as to any extra benefits for products containing CBD (cannabidiol). If you decide to purchase our products, you are drawing your own opinions as to any additional benefits or use of these products may provide. Your acceptance of the terms of purchase means you agree to and understand we are making no claims about our products. These products are not intended to be purchased by anyone under the age of 21 and purchasers agree not to resell these products to any other party, individual or business.
Medical Information/Conditions: Any content on this site related to medical conditions and their treatment is general in nature and is intended only for educational and general information purposes. Nothing on this site is a substitute for professional medical consultation advice. Only your doctor or other health care professional can determine if a medical treatment is appropriate for you.
Oksana V –
I’ve been using Arti-Rub for five days and I can already feel the swelling in my hands starting to go down. I’ve dealt with arthritis for a long time and nothing has worked this fast. Goes on smooth, no grease, no smell. Genuinely surprised by how quickly it’s working.
DB Stevens –
Purblend’s ReLiever and Arti-Rub work better for me than anything else I’ve tried.
I’m 65 and have chronic lower back pain from old injuries, slight displacement of all five lumbar vertebrae, and arthritis in my lower back and a few other places. The pain is always there to some degree, and sometimes it’s severe enough to leave me bedridden after even modest exertion. Traditional treatments and products have provided very little relief over the years.
With ReLiever (and Arti-Rub as well), my pain decreases dramatically within about an hour of application. Before using these products, I was always aware of the pain—sometimes just a dull ache, other times sharp pain when bending, squatting, getting up from a chair, climbing stairs, or even walking. Since I started using them five days ago, I’ve had long stretches where I suddenly realize I haven’t thought about my back at all. No pain. For someone who’s lived with constant pain for years, that’s a pretty remarkable feeling.
Everyone responds differently, but I was honestly surprised by how effective these products have been. After decades of trying things that didn’t help much, and hearing over and over that chronic pain is just something you learn to live with, I’d become pretty cynical. It actually took me several days to accept that the relief was real and not just wishful thinking.
I still find myself processing that. Part of me is incredibly grateful to have found something that helps, and part of me can’t help wondering why I spent so many years believing there simply weren’t effective options available. Maybe that’s not entirely fair, but it’s an emotion that comes up when you’ve lived with pain for a long time and suddenly experience real relief.
Most importantly, though, I’m grateful. After years without a pain-free day, it’s wonderful to have something that makes such a noticeable difference.
Both Arti-Rub and ReLiever work similarly for me and begin working within about an hour. Arti-Rub is a solid gel stick, while ReLiever is a lotion. I prefer ReLiever because it absorbs quickly and isn’t oily. Arti-Rub leaves a temporary film that can transfer to clothing or furniture, though it doesn’t stain. Both products have a noticeable cannabis scent at first, but it fades over time. I hope this helps someone else. It took a lot to convince me, but in a market crowded with products that promise far more than they deliver, these have been genuinely worthwhile.